Pure Melissa Essential Oil (Melissa officinalis) Melissa Oil is extremely good for headaches, depression, nervous anxiety, palpitations and insomnia. Melissa Oil is a pale yellow liquid with a light, fresh Lemony aroma. The therapeutic properties of melissa Oil are antidepressant, antispasmodic, bactericidal, carminative, cordial, diaphragmatic, demagogue, febrifuge, hypotensive, nervine, sedative, stomachic, sudorific, a stimulant for the nervous system, and a tonic for the cardiac system.